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How Roundup Weedkiller Can Promote Cancer, New Study Reveals

daily alternative | alternative news - How Roundup Weedkiller Can Promote Cancer, New Study Reveals

Roundup herbicide (glyphosate) is in our air, rain, groundwater, soil and most food in the U.S., and an increasing body of research reveals it has cancer-promoting properties.

Researchers from the Indian Institute of Toxicology Research have recently confirmed the carcinogenic potential of Roundup herbicide using human skin cells (HaCaT ) exposed to extremely low concentrations of the world’s best selling herbicide.

The researchers previously reported on glyphosate’s tumor promoting potential in a two-stage mouse skin carcinogenesis model[i] through its disruption of proteins that regulate calcium (Ca2+- ) signaling and oxidative stress (SOD 1), but were unable in these investigations to identify the exact molecular mechanisms behind how glyphosate contributes to tumor promotion.

The new study, published in the peer-reviewed journal ISRN Dermatology,[ii] sought out to clarify the exact mode of tumorigenic action, finding the likely mechanism behind glyphosate’s cancer promoting properties is through the downregulation of mitochondrial apoptotic (self-destructive) signaling pathways, as well as through the disruption of a wide range of cell signaling and regulatory components. Cell proliferative effects were induced by concentrations lower than .1 mM, and as low as 0.01 mM, which is four orders of magnitude lower than concentrations commonly used in GM agricultural applications (e.g. 50 mM). The fact that lower concentrations were more effective at inducing proliferation than higher concentrations (which suppressed cell growth), indicates that Roundup is a potent endocrine disrupter, and further highlights why conventional toxicological risk assessments are inadequate because they do not account for the fact that as concentrations are reduced certain types of toxicity — e.g. endocrine disruption — actually increase.

The researchers used the product Roundup Original (glyphosate 41%, polyethoxethyleneamine (POEA) ≅15%—Monsanto Company, St. Louis, MO, USA), and observed the following changes to human skin cells induced through exposure to this chemical mixture:

Significant increases in cell proliferation (via disruption of CA2+ levels, i.e. decreased levels)

Increases oxidative stress, as measured by levels of ROS (reactive oxygen species)

Cell-cycle dysregulation, marked by an accumulation of cells in S-phase (hallmark feature of cancer)

Increased proliferating cell nuclear antigen (PCNA), a marker for increased cell proliferation

Increased Bromodeoxyuridin (BrdU), a marker for increased cell proliferation

Decreases in the level of the protein IP3R1, an indication of resistance to cell death

Increases in Bcl-2 protein, a tumor promoter gene product

Decreases in Bax proteins, a tumor suppressor gene product

Caspase suppression (associated with prevention of cell death)

Changes in the expression of the Ca2+- binding family of proteins (S100 family) S100A6/S100A9, associated with various cancers.

It is important to emphasize that while the researchers observed cell proliferation-associated changes in the expression of the Ca2+- binding proteins S100A6/A9 following glyphosate exposure to human skin cells, the implications of these findings reach beyond the skin cell lineage. They explained that related modifications of the expression pattern of S100A6/A9 protein have also been found in “hepatocellular carcinoma [15], lung cancer [16], colorectal cancer [17], and melanoma [18].”

 

daily alternative | alternative news – How Roundup Weedkiller Can Promote Cancer, New Study Reveals

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Health & Science

Google Now Has Access To Millions of Patients’ Medical Records

A controversial deal between tech giant Google and the National Health Service (NHS) will allow artificial intelligence units access to 1.6 million confidential medical records. Since 2014, Google has partnered with several scientists in an attempt to understand human health, but a new report reveals the data gathering goes far beyond what was originally anticipated.

According to documents obtained by the New Scientist, the data sharing agreement between Google-owned artificial intelligence company DeepMind and the Royal Free NHS Trust gives access to the sensitive healthcare data of millions of NHS patients. The chilling and wide-reaching deal allows DeepMind access to the medical records of the 1.6 million people passing annually through the three London hospitals owned by the Trust — Barnet, Chase Farm, and the Royal Free.

The Google-owned A.I. firm announced in February it was working with the NHS to build an app called Streams — intended to help hospitals monitor patients with kidney disease. However, the new information has revealed that the extent of the data being shared goes much further and includes logs of day-to-day hospital activity, records of the location and status of patients, and even logs of who visits them and when.

Results of pathology and radiology tests are also shared, as is information from critical care and accident and emergency departments. In addition, DeepMind’s access to the centralised records of all NHS hospital treatments in the U.K. means the tech company can access historical data from the last five years, all while receiving a continuous stream of new data.

At the same time, DeepMind is developing a platform called Patient Rescue, which uses hospital data streams to build tools to carry out analysis and support diagnostic decisions. The New Scientist explained how it works:

Comparing a new patient’s information with millions of other cases, Patient Rescue might be able to predict that they are in the early stages of a disease that has not yet become symptomatic, for example. Doctors could then run tests to see if the prediction is correct.

While the Royal Free has not yet responded to the question of what — if any — opt-out mechanisms are available to patients, the New Scientist suggests this is unlikely to be a straightforward process. Despite the agreement stating Google cannot use the data in any other part of the company’s business, many will be seriously wary of the access the online tech giant now has to the confidential data of millions of people.

As the New Scientist wrote:

Data mining is the name of the game in the burgeoning field of machine learning and artificial intelligence, and there’s no company in the world better at that than Google.

 

daily alternative | alternative news – Google Now Has Access To Millions of Patients’ Medical Records

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